After graduating from secondary grammar school in Brno (1968), he studied composition at the Janacek Academy of Music and Dramatic Arts in Brno (1968 - 1974) with Ctirad Kohoutek. Later on he continued his training as a composer with post-graduate studies in experimental and electroacoustic music at the same school under Ctirad Kohoutek, Alois Pinos, Miloslav Istvan, Rudolf Ruzicka and Arnost Parsch (1976 - 1979). Then he completed his studies at the Faculty of Philosophy of Charles University in Prague, where he studied musicology (1980 - 1985, PhDr., 1987). At the beginning of his professional music career he was a teacher in Moravia (at first at secondary grammar school, then at music school). In 1979 he moved to Prague where he worked as recording producer for Supraphon (1979) and Panton (1980 - 1990). From 1991 to 1994 he was employed as a Czech school inspector, and was appointed the head of department of primary and secondary music schools. Since 1995 he works in Czech Museum of Music (department of the National Museum) where he is in charge of sound archives (historical sound recordings). He also teaches theory of music at several Conservatories in Prague. In his first creative period he was primarily interested in contemporary music principles (atonality, dodecaphony and aleatoric music) and in the method of 'Project Music Composition' invented by his teacher Ctirad Kohoutek (Studies for piano, Accordeonis Soni, String Quartet no.1, Piano Trio, The Road to the Castle). In later creative periods he uses the methods based on modal and tonal principles and on more horizontal musical thought (Warning, Gaudeamus Omnes, Sympathy for Bass Clarinet and Piano, Meeting for Dulcimer and Marimba, Inventions for Dulcimer). His compositions were played by Prague Symphony Orchestra, Brno Philharmonic Orchestra, Brno String Quartet, Prague Madrigalists, Due Boemi di Praga, Prague Cathedral Choir a.o.

Vojtěch Mojzis has received awards for his music in the Czechoslovak Republic Young Composers' Competition for his symphonic picture Vinicne Sumice, as well as in the national young composers' competition 'Generace' (held in Ostrava, Moravia) for String Quartet No.2, and Sonata for Piano and French Horn. He is a member of the Association of Composers, Interpreters and Musicologists in Prague, and for several years was chairman of the Society for Contemporary Music 'Pritomnost'.